The genotoxicity assessment of chemicals in food is a crucial part of risk assessment. Over the years, EFSA has developed several guidance documents with the aim to harmonise the genotoxicity testing strategies and methodologies.
This self-paced training is divided in four modules designed by the Fraunhofer Institute for EFSA. An overview is provided addressing the biological backgrounds, the mechanisms of genotoxicity, relevant testing endpoints, batteries and non-testing methods (e.g., QSARs, read-across). The quality, relevance and reliability criteria for interpreting genotoxicity studies are presented, as well as the methodologies and approaches for genotoxicity assessment (i.e., TTC, MOE) and the weight of evidence (WoE) approach.
Genotox Simon Lee modf (Unplash)_logoEFSA2.png- Course Owner: Alejandro GARCIA LOPEZ