In line with this increasing focus on interdisciplinarity, in June 2021, we organised the conference ‘Methods and Models in Biomedical Research: Building Bridges’. A collaboration between the Champalimaud Foundation, the JRC Systems Toxicology Unit, and FRESCI, the workshop created an opportunity for cross-disciplinary discussions across diverse communities in biomedical sciences (agency, regulatory, industry, researchers) to talk freely about methods and models, and explore common ground. This series of podcasts, hosted by Annamaria Carusi, a philosopher of science and technology, extends the conversations started at that workshop.